SREBP1 (SREBF1) (Center) Rabbit Polyclonal Antibody

CAT#: AP18209PU-N

SREBP1 (SREBF1) (Center) rabbit polyclonal antibody


USD 450.00

2 Weeks*

Size
    • 400 ul

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Specifications

Product Data
Applications WB
Recommended Dilution ELISA: 1/1,000.
Western blotting: 1/100 - 1/500.
Reactivities Human
Host Rabbit
Clonality Polyclonal
Immunogen KLH conjugated synthetic peptide selected from the Center region of human SREBF1
Specificity This antibody reacts to SREBF1.
Formulation PBS with 0.09% (W/V) sodium azide
State: Liquid purified Ig
Concentration lot specific
Purification Affinity chromatography on Protein A
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens sterol regulatory element binding transcription factor 1 (SREBF1), transcript variant 1
Background SREBF1 is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family.
Synonyms SREBP-1, BHLHD1
Reference Data
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Insulin signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.