PMP22 Rabbit Polyclonal Antibody

CAT#: AP20266PU-N

PMP22 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of GAS3 antibody (AP20266PU-N) in extracts from MDA-MB-435 cells.

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  Immunohistochemistry analyzes of GAS3 antibody (AP20266PU-N) in paraffin-embedded human brain tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
  immunohistochemistry on paraffin sections: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This detects endogenous levels of GAS3 protein.
• Formulation: Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography using epitope-specific immunogen; purity is > 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Predicted Protein Size: ~ 22 kDa
• Gene Name: Homo sapiens peripheral myelin protein 22 (PMP22), transcript variant 1
• Database Link:
  Entrez Gene 24660 RatEntrez Gene 5376 Human
  UniProt ID Q01453
• Background: PMP 22 is a 22 kDa glycoprotein expressed in the compact myelin of the peripheral nervous system. In the peripheral nervous system, PMP 22 is produced by myelinating Schwann cells and is coexpressed with the genes for myelin basic protein (MBP) during nerve development and regeneration. Alterations in the level of this protein cause several genetic human diseases. If the protein is duplicated, patients develop Charcot Marie Tooth disease. If one copy of the gene is deleted, they suffer from the inherited tendency to pressure palsies.
• Synonyms: PMP-22, GAS3, GAS-3, Peripheral myelin protein 22

Reference Data

• Protein Families: Transmembrane