CIITA Rabbit Polyclonal Antibody

CAT#: AP20521PU-N

CIITA rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of CIITA antibody (Cat.-No.: AP20521PU-N) in extracts from K562 cells.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of CIITA protein.
  (region surrounding Thr740)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Predicted Protein Size: ~ 123 kDa
• Gene Name: Homo sapiens class II major histocompatibility complex transactivator (CIITA), transcript variant 2
• Database Link:
  Entrez Gene 12265 MouseEntrez Gene 85483 RatEntrez Gene 4261 Human
• Background: The transactivator CIITA regulates basal and interferon-induced expression of MHC class II genes. CIITA restores expression of all MHC II gene expression in mutant cells and corrects regulatory defects of those genes. Activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. CIITA may act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter.
• Synonyms: MHC2TA

Reference Data

• Protein Pathways: Antigen processing and presentation, Primary immunodeficiency