AKAP1 Rabbit Polyclonal Antibody

CAT#: AP20535PU-N

AKAP1 rabbit polyclonal antibody, Aff - Purified


USD 407.00

2 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Applications IF, IHC, WB
Recommended Dilution

Western blot: 1/500-1/1000.
Immunofluorescence: 1/50-1/200.
Immunohistochemistry on Paraffin Sections: 1/50-1/200.

Reactivities Human
Host Rabbit
Clonality Polyclonal
Specificity This antibody detects endogenous levels of AKAP149 protein.
(region surrounding asn306)
Formulation Phosphate buffered saline (PBS), pH~7.2
State: Aff - Purified
State: Liquid purified Ig fraction (>95% pure by SDS-PAGE
Preservative: 0.05% Sodium Azide
Concentration 1.0 mg/ml
Purification Affinity-Chromatography using epitope-specific immunogen
Conjugation Unconjugated
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Predicted Protein Size ~ 90 kDa
Gene Name Homo sapiens A-kinase anchoring protein 1 (AKAP1), transcript variant 1
Background The type II cAMP-protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is thought to be mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this specific localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins. This family of proteins has been designated A-kinase anchoring proteins (AKAP). Members of this family, including MAP2 (microtubule-associated protein 2), neuronally expressed AKAP 79 and AKAP 150, and the DNA binding AKAP 95, display differential tissue specificity and localization. Evidence suggests that AKAP 79 and AKAP 150 are both capable of anchoring PKA to postsynaptic densities (PSD), which are a network of proteins located on the internal surfaces of excitatory synapses.
Synonyms AKAP149, PRKA1, AKAP-1
Reference Data
Protein Families Druggable Genome, Transmembrane

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.