IL4R Rabbit Polyclonal Antibody

CAT#: AP20570PU-N

IL4R rabbit polyclonal antibody, Aff - Purified


USD 370.00

2 Weeks*

Size
    • 100 ug

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Other products for "IL4R"

Specifications

Product Data
Applications IHC, WB
Recommended Dilution Western Blot: 1/500-1/1000.
Immunohistochemistry on Paraffin Sections
: 1/50-1/200.
Reactivities Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to amino acids 220-265 of Human IL-4Rα.
Specificity This antibody detects endogenous levels of IL-4R alpha protein. (region surrounding Ser254)
Formulation Phosphate buffered saline (PBS), pH~7.2
State: Aff - Purified
State: Liquid purified Ig fraction (> 95% by SDS-PAGE)
Preservative: 0.05% Sodium Azide
Concentration 1.0 mg/ml
Purification Affinity Chromatography using epitope-specific immunogen
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Predicted Protein Size ~ 88 kDa
Gene Name Homo sapiens interleukin 4 receptor (IL4R), transcript variant 1
Background The IL-2 receptor is a multicomponent complex consisting of three subunits, alpha, beta and gamma, each of which is required for high affinity binding of IL-2. The alpha chain functions primarily in binding IL-2, whereas the beta and gamma chains contribute to IL-2 binding and are essential to IL-2-induced activation of signaling pathways leading to T cell growth. Both IL-4R and IL-7R were initially described as single chain, high-affinity ligand-binding cytokine receptors. However, it is now well established that the IL-2Rgamma chain functions as a second subunit of the high affinity IL-4R and IL-7R receptors. Consequently, the originally described subunits of these latter receptors are now referred to as IL-4Ralpha and IL-7Ralpha, respectively, while the common subunit is referred to as gammac. Although the common gamma chain enhances ligand binding in these three cytokine receptors, it has no capacity to bind these ligands on its own. There is evidence that the gammac chain is also a subunit of IL-13R.
Synonyms Interleukin-4 receptor alpha chain, IL-4R-alpha, IL4RA, 582J2.1, IL4 Receptor alpha
Reference Data
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.