Neuropeptide Y (NPY) Rabbit Polyclonal Antibody

CAT#: AP20664PU-N

Neuropeptide Y (NPY) rabbit polyclonal antibody, Aff - Purified

Product Images

Immunohistochemistry (IHC) analyzes of NPY antibody (Cat.-No.: AP20664PU-N) in paraffin-embedded human brain tissue.

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry on paraffin sections: 1/50 - 1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of NPY protein.
  (region surrounding Pro94)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 11 kDa
• Gene Name: Homo sapiens neuropeptide Y (NPY)
• Database Link:
  Entrez Gene 24604 RatEntrez Gene 109648 MouseEntrez Gene 4852 Human
• Background: A gene located on chromosome 7p15.1 encodes a 36-amino acid protein designated NPY (Neuropeptide Y). NPY consists of a polyproline stretch followed by an amphipathic alphahelix. NPY shares a 50% amino acid homology with pancreatic polypeptide gene (PP). The NPY hormone family consists of NPY, PP and peptide YY. NPY is expressed throughout the central and peripheral nervous system, particularly in the deep layers of the cortex and smaller cell bodies in the white matter. NPY interacts with the Y-receptor family of G-protein coupled receptors. NPY interacts with NPY receptor Y1 to increase corticotropin levels and decrease noradrenaline levels in the hypothalamus. Through interactions in the hypothalus, NPY plays important roles in the regulation of energy balance by stimulating food intake. NPY favors energy storage by increasing lipoprotein lipase activity in white adipose tissue. A leucine(7)-to- proline(7) polymorphism has been implicated in an increase in alcohol preference, and decrease in cholesterol metabolism.
• Synonyms: OTTHUMP00000201946; OTTHUMP00000201947; PYY4

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Adipocytokine signaling pathway