GABA A Receptor alpha 1 (GABRA1) Rabbit Polyclonal Antibody

CAT#: AP20674PU-N

GABA A Receptor alpha 1 (GABRA1) rabbit polyclonal antibody, Aff - Purified

Product Images

Immunohistochemistry (IHC) analyzes of GABAA Ralpha1 antibody (Cat.-No.: AP20674PU-N) in paraffin-embedded human brain tissue.

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry on paraffin sections: 1/50 - 1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of GABAA Ralpha1 protein.
  (region surrounding Leu361)
• Formulation: Phosphate buffered saline (PBS), pH 7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens gamma-aminobutyric acid type A receptor alpha1 subunit (GABRA1), transcript variant 1
• Database Link:
  Entrez Gene 14394 MouseEntrez Gene 29705 RatEntrez Gene 2554 Human
• Background: GAD-65 and GAD-67, glutamate decarboxylases of 65 and 67 kDa, respectively, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA Ralpha1-6, GABAA Rbeta1-3, GABAA Repsilon, GABAA Rdelta, GABAA Rgamma1-3, GABAA Rrho1 and GABAA Rrho2. The GABAB family is composed of GABAB R1alpha and GABAB R1beta. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2 and -3). The GABA transporters function to terminate GABA action.
• Synonyms: GABRA-1, GABA A receptor subunit alpha-1

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Cys-loop Receptors, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction