NCR1 Rabbit Polyclonal Antibody

CAT#: AP21199PU-N

NCR1 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of NKp46 antibody (Cat.-No.: AP21199PU-N) in extracts from A549 cells.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of CD335 / NKp46.
  (region surrounding Pro176)
• Formulation: Phosphate buffered saline (PBS), pH 7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 15 mM sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography using epitope-specific immunogen(> 95% pure by SDS-PAGE)
• Predicted Protein Size: ~ 38 kDa
• Gene Name: Homo sapiens natural cytotoxicity triggering receptor 1 (NCR1), transcript variant 1
• Database Link:
  Entrez Gene 9437 Human
• Background: NKp46 (lymphocyte antigen 94, LY94) is a natural cytotoxicity receptor that belongs to the immunoglobulin superfamily and is expressed by all resting or activated NK cells, but not on T cells or B cells. The NKp46 cDNA encodes a 304 amino acid type I transmembrane protein with an extracellular region preceded by a 21 residue signal peptide and two cysteine-bridged C2-type Ig-like domains. A stem connects the extracellular domain to a 19 amino acid, arginine containing-transmembrane domain. NKp46 is involved in natural cytotoxicity and is involved in the recognition and lysis of both human and murine tumor cells.
• Synonyms: NCR1, LY94, NKp46

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Natural killer cell mediated cytotoxicity