GABA A Receptor alpha 4 (GABRA4) (349-361) Goat Polyclonal Antibody

CAT#: AP22583PU-N

GABA A Receptor alpha 4 (GABRA4) (349-361) goat polyclonal antibody, Aff - Purified


USD 440.00

2 Weeks*

Size
    • 50 ug

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Specifications

Product Data
Applications ELISA, IHC, WB
Recommended Dilution ELISA: 1/16000.
Immunohistochemistry on Paraffin Sections: 2.5 µg/ml.
Western Blot: 0.1 - 0.3 µg/ml.
Reactivities Human
Host Goat
Clonality Polyclonal
Immunogen Synthetic peptide from an internal region of human GABRA4 (NP_000800.2)
Specificity This antibody detects GABRA4 (Internal).
Formulation Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA
State: Aff - Purified
State: Liquid Ig fraction
Concentration lot specific
Purification Immunoaffinity chromatography
Storage Store (in aliquots) at -20 °C. Dilute only prior to immediate use. Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens gamma-aminobutyric acid type A receptor alpha4 subunit (GABRA4), transcript variant 1
Background Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABA-A receptor subtype. GABA-A receptors are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABA-A receptor is a multimeric subunit complex. To date six alpha, four beta, and four gamma subunits, plus alternative splicing variants of some of these subunits, have been identified. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor.
Synonyms GABRA-4, GABAA Receptor alpha-4
Reference Data
Protein Families Druggable Genome, Ion Channels: Cys-loop Receptors, Transmembrane
Protein Pathways Neuroactive ligand-receptor interaction

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.