BAG3 (C-term) Goat Polyclonal Antibody

CAT#: AP23023PU-N

BAG3 (C-term) goat polyclonal antibody, Purified

Product Images

Immunohistochemistry Image: Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Immunohistochemistry Image: Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Immunohistochemistry Image: Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/8000.
  Immunohistochemistry on Paraffin Sections: 3.75 µg/ml.
  Western Blot.
• Reactivities: Human
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from C-terminus of human BAG3
• Specificity: This antibody detects BAG3 (C-term).
• Formulation: Tris saline buffer, pH 7.3 containing 0.5% BSA as stabilizer and 0.02% sodium azide as preservative
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: 0.5 mg/ml
• Purification: Immunoaffinity chromatography
• Gene Name: Homo sapiens BCL2 associated athanogene 3 (BAG3)
• Database Link:
  Entrez Gene 9531 Human
• Background: This protein has a number of names including Bis, CAIR-1, and BAG-3 and belongs to a family of proteins that share the BAG domain. BAG-3 binds to HSP-70 and inhibits Hsp-mediated proteasomal degradation by virtue of its C-terminal BAG domain that interacts with the ATP binding site of Hsp-70. This protein has also been shown to interact with Bcl-2 and by it self exerts weak anti-apoptotic activity but is synergistic with Bcl-2 in preventing Bax-induced and Fas-mediated apoptosis.
• Synonyms: BAG-3, BIS, Docking protein CAIR-1

Reference Data

• Protein Families: Druggable Genome