PTCH1 (1431-1442) Goat Polyclonal Antibody

CAT#: AP23037PU-N

PTCH1 (1431-1442) goat polyclonal antibody, Aff - Purified

Product Images

Immunohistochemistry Image: Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)

• 

  Immunohistochemistry Image: Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC
• Recommended Dilution: ELISA: 1/8000.
  Immunohistochemistry on Paraffin Sections: 3.75 µg/ml.
• Reactivities: Bat, Canine, Equine, Human, Monkey
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from C-terminus of human PTCH1
• Specificity: This antibody detects PTCH1 (C-term).
  It is expected to recognise all reported isoforms.
• Formulation: Tris saline buffer, pH 7.3, 0.5% BSA, 0.02% sodium azide
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Storage: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens patched 1 (PTCH1), transcript variant 1b
• Database Link:
  Entrez Gene 5727 Human
• Background: PTCH1 / Patched 1 is a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor.
• Synonyms: PTCH, PTC1, PTC, Patched 1

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer