TRPM2 (1139-1150) Goat Polyclonal Antibody

CAT#: AP23104PU-N

TRPM2 (1139-1150) goat polyclonal antibody, Aff - Purified

Product Images

Brain, cortex, Human: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Pancreas, Human: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 3.75 µg/ml.
• Reactivities: Human, Monkey
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from internal region of human TRPM2 (NP_003298.1)
• Specificity: This antibody detects TRPM2 / TRPC7 (Internal).
• Formulation: Tris saline, pH 7.3 containing 0.02% sodium azide as preservative and 0.5% BSA as stabilizer
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens transient receptor potential cation channel, subfamily M, member 2 (TRPM2), transcript variant 1
• Database Link:
  Entrez Gene 7226 Human
• Background: Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD+), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress.
• Synonyms: EREG1, KNP3, LTRPC2, LTrpC-2, LTrpC2

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane