Annexin A1 (ANXA1) (N-term) Rabbit Polyclonal Antibody

CAT#: AP23249PU-N

Annexin A1 (ANXA1) (N-term) rabbit polyclonal antibody, Aff - Purified

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1:1000; Incubate membrane with diluted antibody in 5% w/v nonfat dry milk, 1× TBS, 0.05% Tween-20 at 4°C with gentle shaking, overnight.
• Reactivities: Canine, Human, Monkey
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptides (KLH-coupled) corresponding to residues within the aminoterminal residues of human annexin A1
• Specificity: This antibody detects detects endogenous levels of total annexin A1 protein.
• Formulation: State: Aff - Purified
• Storage: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens annexin A1 (ANXA1)
• Database Link:
  Entrez Gene 702946 MonkeyEntrez Gene 301 Human
• Background: The annexin superfamily consists of 13 calcium or calcium and phospholipid binding proteins with high biological and structural homology. Annexin-1 (ANXA1) is the frst characterized member of the annexin family of proteins able to bind to cellular membranes in a calcium-dependent manner which promotes membrane fusion and is involved in endocytosis. Annexin A1 has anti-infammatory properties and inhibits phospholipase A2 activity. Annexin A1 can accumulate on internalized vesicles after EGF-stimulated endocytosis,suggesting that it may be required for a late stage in inward vesiculation.Phosphorylation by PKC, EGFR and Chak1 results in inhibition of annexin A1 function. Annexin A1 has also been identifed as one of the ‘eat-me’ signals on apoptotic cells to be recognised and ingested by phagocytes. Annexin A1, as an endogenous anti-infammatory mediator, has roles in many diverse cellular functions, such as membrane aggregation, infammation, phagocytosis,proliferation, apoptosis, and tumorigenesis and cancer development.
• Synonyms: ANX1, LPC1, Annexin-1, Annexin I, Lipocortin I, Calpactin II, Chromobindin-9, p35
• Note: Molecular weight: 35 kDa

Reference Data

• Protein Families: Druggable Genome