CYB5R3 (C-term) Goat Polyclonal Antibody

CAT#: AP23662PU-N

CYB5R3 (C-term) goat polyclonal antibody, Aff - Purified


USD 375.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Applications ELISA, IHC, WB
Recommended Dilution Peptide ELISA: 1/32000 (Detection Limit).
Western Blot: 0.01-0.03 µg/ml. Approx 37kDa band observed in Human Placenta, Testis and Umbilical Cord lysates. 
Immunohistochemistry on Paraffin Sections: 3-5 µg/ml. In paraffin embedded Human Adrenal Gland shows heavy vesicular/granular staining in the cytoplasm of medular cells.
Reactivities Human
Host Goat
Clonality Polyclonal
Immunogen Synthetic peptide from the C-terminus of human CYB5R3 (NP_000389.1; NP_001123291.1; NP_001165131.1).
Specificity This antibody is expected to recognize all three reported isoforms (NP_000389.1, NP_001123291.1 and NP_001165131.1).
Formulation Tris saline, pH~7.3
State: Aff - Purified
State: Liquid purified IgG fraction.
Stabilizer: 0.5% BSA
Preservative: 0.02% Sodium Azide
Concentration lot specific
Purification Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens cytochrome b5 reductase 3 (CYB5R3), transcript variant 1
Background CYB5R3 belongs to the flavoprotein pyridine nucleotide cytochrome reductase family and contains 1 FAD-binding FR-type domain. There are two isoforms, NADH-cytochrome b5 reductase 3 membrane bound form and NADH-cytochrome b5 reductase 3 soluble form. Its functions include desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. Defects in CYB5R3 are the cause of hereditary methemoglobinemia (HM). There are three forms of this disease: type 1 (HM1) in which the enzyme is only deficient in erythrocytes with a mild cyanosis; type 2 (HM2), in which the enzyme is completely deficient; type 3 (HM3) where the deficiency is seen in all blood cells. Type 2 is a severe form accompanied with mental retardation and neurological impairment.
Synonyms NADH-cytochrome b5 reductase 3, B5R, DIA1, Diaphorase-1
Note Calculated Molecular Weight: 38.2kDa (NP_001165131.1).
Reference Data
Protein Families Druggable Genome
Protein Pathways Amino sugar and nucleotide sugar metabolism

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