ATF6 (C-term) Goat Polyclonal Antibody

CAT#: AP23812PU-N

ATF6 (C-term) goat polyclonal antibody, Aff - Purified

Product Images

Human Uterus (formalin-fixed, paraffin-embedded) stained with ATF6 antibody at 2.5 ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Applications: ELISA, IHC
• Recommended Dilution: ELISA: 1/8000.
  Immunohistochemistry on Paraffin Sections: 2.5 µg/ml.
• Reactivities: Human, Rabbit
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from C-terminus of human ATF6
• Specificity: This antibody reacts to the C-term of ATF6.
• Formulation: Tris saline buffer, pH 7.3 containing 0.5% BSA as stabilizer and 0.02% sodium azide as preservative
  State: Aff - Purified
  State: Liquid purfied Ig fraction
• Concentration: 0.5 mg/ml
• Purification: Immunoaffinity Chromatography
• Gene Name: Homo sapiens activating transcription factor 6 (ATF6)
• Database Link:
  Entrez Gene 226641 MouseEntrez Gene 22926 Human
• Background: Activating Transcription Factor 6 (ATF6) is a type II transmembrane glycoprotein located on the ER membrane. In response to ER stress ATF6 is cleaved and the N-terminus including the leucine zipper (which faces the cytosol) moves to the nucleus. Once in the nucleus ATF6 binds to the ER stress response elements in ER stress genes. Site-1 and site-2 protease enzymes that process sterol regulatory binding proteins in response to cholesterol derivation cleave ATF6.
• Synonyms: ATF-6, Activating transcription factor 6 alpha

Reference Data

• Protein Families: Transcription Factors
• Protein Pathways: Alzheimer's disease