CD95 (FAS) (323-327) Rabbit Polyclonal Antibody
Other products for "FAS"
Specifications
Product Data | |
Applications | WB |
Recommended Dilution | Western blot: 1:1000. |
Reactivities | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Peptide sequence around aa.323~327 derived from human Fas . |
Specificity | This antibody detects endogenous level of total Fas protein. |
Formulation | Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol State: Aff - Purified State: Liquid Ig fraction |
Concentration | lot specific |
Purification | Affinity-chromatography using epitope-specific peptide |
Storage | Store (in aliquots) at -20 °C. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | Homo sapiens Fas cell surface death receptor (FAS), transcript variant 1 |
Database Link | |
Background | Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). |
Synonyms | FASLG receptor, Apo-1 antigen, APT1, FAS1, TNFRSF6 |
Note | Molecular weight: 40-50 kDa |
Reference Data | |
Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein |
Protein Pathways | Allograft rejection, Alzheimer's disease, Apoptosis, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Graft-versus-host disease, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, p53 signaling pathway, Pathways in cancer, Type I diabetes mellitus |
Documents
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.