TAB2 (161-173) Goat Polyclonal Antibody

CAT#: AP31014PU-N

TAB2 (161-173) goat polyclonal antibody, Aff - Purified

Product Images

Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 3.75 - 7.5 µg/ml.
• Reactivities: Human
• Host: Goat
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from positions 161-173 of human TAB2 (NP_055908.1)
• Specificity: This antibody reacts to TGF-Beta Activated kinase 1/MAP3K7 Binding Protein 2 (TAB2) at aa161-173.
• Formulation: Tris saline buffer, pH 7.3 containing 0.5% BSA as stabilizer and 0.02% sodium azide as preservative
  State: Aff - Purified
  State: Liquid purfied Ig fraction
• Concentration: 0.5 mg/ml
• Purification: Immunoaffinity Chromatography
• Gene Name: Homo sapiens TGF-beta activated kinase 1/MAP3K7 binding protein 2 (TAB2), transcript variant 1
• Database Link:
  Entrez Gene 23118 Human
• Background: The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappa B (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.
• Synonyms: TAK1-binding protein 2, Tab-2, Mitogen-activated protein kinase kinase kinase 7-interacting protein 2

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: MAPK signaling pathway, NOD-like receptor signaling pathway, Toll-like receptor signaling pathway