Smad Interacting Protein 1 (ZEB2) (C-term) Rabbit Polyclonal Antibody

CAT#: AP31202PU-N

Smad Interacting Protein 1 (ZEB2) (C-term) rabbit polyclonal antibody, Purified

Product Images

Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)

• 

  Human Small Intestine, Submucosal Plexus: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IF, IHC, WB
• Recommended Dilution: ELISA.
  Immunocytochemistry.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 1 - 2 µg/ml.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: ZEB2 antibody was raised against an 18 amino acid synthetic near the carboxy terminus of Human ZEB2.
• Specificity: This antibody reacts to the C-term of ZEB2.
• Formulation: PBS containing 0.02% Sodium Azide as preservative
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: 1 mg/ml
• Purification: Immunoaffinity Chromatography
• Gene Name: Homo sapiens zinc finger E-box binding homeobox 2 (ZEB2), transcript variant 2
• Database Link:
  Entrez Gene 24136 MouseEntrez Gene 311071 RatEntrez Gene 9839 Human
• Background: ZEB2, initially identified as Smad interacting-protein 1, is normally located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Like the homologous ZEB1, ZEB2 inhibits the transcription of the E-cadherin gene and induces epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing, in vitro. ZEB2 can also protect cells from DNA damage-induced apoptosis, suggesting that its expression may contribute to tumor progression. Recent evidence has shown that ZEB2 is often observed in the cytoplasm in numerous cancer tissues, indicating that its localization may be regulated in normal and tumor tissues. Mutations in this gene are also associated with Hirschsprung disease/Mowat-Wilson syndrome.
• Synonyms: ZFX1B, ZEB2, SMADIP1, SIP1, KIAA0569

Reference Data

• Protein Families: Druggable Genome, Transcription Factors