KPNA2 (N-term) Rabbit Polyclonal Antibody

CAT#: AP31240PU-N

KPNA2 (N-term) rabbit polyclonal antibody, Purified

Product Images

Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 1 - 2 µg/ml.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide - KLH conjugated
• Specificity: This antibody reacts to the N-term of KPNA2.
• Formulation: PBS containing 0.02% sodium azide as preservative
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity chromatography
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens karyopherin subunit alpha 2 (KPNA2), transcript variant 2
• Database Link:
  Entrez Gene 16647 MouseEntrez Gene 85245 RatEntrez Gene 3838 Human
• Background: The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination.
• Synonyms: Karyopherin alpha-2, SRP1-alpha, RAG cohort protein 1, RCH1

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency