CIITA (N-term) Rabbit Polyclonal Antibody

CAT#: AP31268PU-N

CIITA (N-term) rabbit polyclonal antibody, Purified

Product Images

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 1 - 2 µg/ml.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide - KLH conjugated
• Specificity: This antibody reacts to the N-term of CIITA.
• Formulation: PBS containing 0.02% sodium azide as preservative
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: 1 mg/ml
• Purification: Immunoaffinity chromatography
• Gene Name: Homo sapiens class II major histocompatibility complex transactivator (CIITA), transcript variant 2
• Database Link:
  Entrez Gene 12265 MouseEntrez Gene 85483 RatEntrez Gene 4261 Human
• Background: This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction.
• Synonyms: MHC2TA

Reference Data

• Protein Pathways: Antigen processing and presentation, Primary immunodeficiency