CIITA (N-term) Rabbit Polyclonal Antibody

CAT#: AP31268PU-N

CIITA (N-term) rabbit polyclonal antibody, Purified


USD 440.00

2 Weeks*

Size
    • 50 ug

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Specifications

Product Data
Applications ELISA, IHC, WB
Recommended Dilution ELISA.
Immunohistochemistry on Paraffin Sections: 5 µg/ml.
Western Blot: 1 - 2 µg/ml.
Reactivities Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide - KLH conjugated
Specificity This antibody reacts to the N-term of CIITA.
Formulation PBS containing 0.02% sodium azide as preservative
State: Purified
State: Liquid purified Ig fraction
Concentration 1 mg/ml
Purification Immunoaffinity chromatography
Gene Name Homo sapiens class II major histocompatibility complex transactivator (CIITA), transcript variant 2
Background This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction.
Synonyms MHC2TA
Reference Data
Protein Pathways Antigen processing and presentation, Primary immunodeficiency

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.