NFATC4 Goat Polyclonal Antibody

CAT#: AP31861PU-N

NFATC4 goat polyclonal antibody, Aff - Purified


USD 375.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Applications ELISA, IHC
Recommended Dilution Peptide ELISA: 1/16000 (Detection Limit).
Western blot: No signal obtained yet but low background observed in MOLT-4, Jurkat, A431, HeLa, Human Brain and Human Heart lysates at upto 2 µg/ml.
Immunohistochemistry on Paraffin Sections: 2.5-3.8 µg/ml. In paraffin embedded Human Placenta shows weak nuclear staining in trophoblasts.
Reactivities Canine, Human, Mouse, Porcine, Rat
Host Goat
Clonality Polyclonal
Immunogen Peptide with sequence from the C Terminus of the protein sequence according to NP_004545.2, NP_001185894.1, NP_001185895.1, NP_001185896.1.
Specificity This antibody is expected to recognise isoform 2 (NP_004545.2), Isoform 3 (NP_001185894.1), Isofrom 4 (NP_001185895.1) and Isofrom 5 (NP_001185896.1).
Formulation Tris buffered saline, pH~7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer
State: Aff - Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 (NFATC4), transcript variant 1
Background The protein is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a pre-existing cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The product of this gene plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4.
Synonyms NF-ATc4
Reference Data
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Axon guidance, B cell receptor signaling pathway, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, VEGF signaling pathway, Wnt signaling pathway

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