TNFRSF1A (20-43) Rabbit Polyclonal Antibody

CAT#: AP33393PU-N

TNFRSF1A (20-43) rabbit polyclonal antibody, Purified

Product Images

Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC, IP, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Immunoprecipitation.
  Western Blot: 1/1000.
• Reactivities: Bovine, Canine, Human, Monkey, Mouse, Rabbit, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: TNFRSF1A antibody was raised against a synthetic peptide based on residues 20-43 of Mouse TNF-R1.
• Specificity: This antibody recognizes TNFRSF1A.
• Formulation: PBS, pH 7,4
  State: Purified
  State: Liquid purified Ig fraction
  Stabilizer: 50% Glycerol
  Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)
• Database Link:
  Entrez Gene 21937 MouseEntrez Gene 25625 RatEntrez Gene 722033 MonkeyEntrez Gene 7132 Human
• Background: TNFRI is a 55 kD transmembrane glycoprotein that also exists as a secreted protein. TNF receptors self assemble through a distinct functional extracellular domain termed PLAD in the absence of ligand. Efficient TNFA binding depends on receptor self assembly. TNFR1 associates with MADD protein through a death domain-death domain interaction. MADD is thought to provide a link to MAP Kinase activation. TNFR1 can also activate NFKbeta via TNF receptor associated factor 2 and the cytoplasmic domain can interact with the JAK/STAT pathway.
• Synonyms: Tumor necrosis factor receptor 1, TNF-R1, TNF-RI, TNFR-I, p55, p60, Tnfrsf1a

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transcription Factors, Transmembrane
• Protein Pathways: Adipocytokine signaling pathway, Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Cytokine-cytokine receptor interaction, MAPK signaling pathway