TNFRSF1A (20-43) Rabbit Polyclonal Antibody
Other products for "TNFRSF1A"
Specifications
Product Data | |
Applications | IHC, IP, WB |
Recommended Dilution | Immunohistochemistry on Paraffin Sections: 5 µg/ml. Immunoprecipitation. Western Blot: 1/1000. |
Reactivities | Bovine, Canine, Human, Monkey, Mouse, Rabbit, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | TNFRSF1A antibody was raised against a synthetic peptide based on residues 20-43 of Mouse TNF-R1. |
Specificity | This antibody recognizes TNFRSF1A. |
Formulation | PBS, pH 7,4 State: Purified State: Liquid purified Ig fraction Stabilizer: 50% Glycerol Preservative: 0.09% Sodium Azide |
Concentration | lot specific |
Purification | Immunoaffinity Chromatography |
Storage | Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | Homo sapiens tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) |
Database Link | |
Background | TNFRI is a 55 kD transmembrane glycoprotein that also exists as a secreted protein. TNF receptors self assemble through a distinct functional extracellular domain termed PLAD in the absence of ligand. Efficient TNFA binding depends on receptor self assembly. TNFR1 associates with MADD protein through a death domain-death domain interaction. MADD is thought to provide a link to MAP Kinase activation. TNFR1 can also activate NFKbeta via TNF receptor associated factor 2 and the cytoplasmic domain can interact with the JAK/STAT pathway. |
Synonyms | Tumor necrosis factor receptor 1, TNF-R1, TNF-RI, TNFR-I, p55, p60, Tnfrsf1a |
Reference Data | |
Protein Families | Druggable Genome, Secreted Protein, Transcription Factors, Transmembrane |
Protein Pathways | Adipocytokine signaling pathway, Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Cytokine-cytokine receptor interaction, MAPK signaling pathway |
Documents
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