Proteinase Activated Receptor 3 (F2RL2) (N-term) Rabbit Polyclonal Antibody

CAT#: AP51496PU-N

Proteinase Activated Receptor 3 (F2RL2) (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of F2RL2 Antibody (N-term) in NCI-H292 cell line lysates (35ug/lane). This demonstrates the F2RL2 antibody detected the F2RL2 protein (arrow).

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  Formalin fixed and paraffin embedded human heart tissue reacted with F2RL2 Antibody (N-term) followed by peroxidase conjugation of the secondary antibody and DAB staining.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/100-1/500.
  Immunohistochemistry on Paraffin Sections: 1/10-1/50.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 20-50 amino acids from the N-terminal region of human F2RL2
• Specificity: This antibody recognizes Human F2RL2 (N-term).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens coagulation factor II thrombin receptor like 2 (F2RL2), transcript variant 1
• Database Link:
  Entrez Gene 2151 Human
• Background: Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL2 is also a member of the protease-activated receptor family and activated by thrombin. F2RL2 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL2 is a cofactor for F2RL3 activation by thrombin. It mediates thrombin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues.
• Synonyms: PAR3, PAR-3, Thrombin receptor-like 2
• Note: Molecular Weight: 42508 Da

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction