GPCR MRGX2 (MRGPRX2) (C-term) Rabbit Polyclonal Antibody

CAT#: AP52746PU-N

GPCR MRGX2 (MRGPRX2) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis in 293 cell line lysates (35ug/lane) using MRGPRX2 antibody. (C-tem). This demonstrates this antibody detected the MRGPRX2 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1/100-1/500.
  Enzyme immunoassay: 1/1000.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 286-316aa) of human MRGPRX2.
• Specificity: This antibody recognizes MRGPRX2 at C-term.
• Formulation: PBS with 0.09% (W/V) Sodium azide
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Purified through a Protein A column followed by peptide affinity purification
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens MAS related GPR family member X2 (MRGPRX2), transcript variant 2
• Database Link:
  Entrez Gene 117194 Human
• Background: MRGPRX2 is the orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled.
• Synonyms: MRGX2
• Note: Molecular Weight: 37099 Da

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane