PTPN22 (C-term) Rabbit Polyclonal Antibody
Other products for "PTPN22"
Specifications
Product Data | |
Applications | WB |
Recommended Dilution | Western blot: 1/100-1/500. |
Reactivities | Human |
Host | Rabbit |
Isotype | Ig |
Clonality | Polyclonal |
Immunogen | Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 662-691aa) of human PTPN22. |
Specificity | This antibody recognizes PTPN22 at C-term. |
Formulation | PBS with 0.09% (W/V) Sodium azide State: Aff - Purified State: Liquid purified Ig fraction |
Concentration | lot specific |
Purification | Purified through a Protein A column followed by peptide affinity purification |
Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
Stability | Shelf life: one year from despatch. |
Gene Name | Homo sapiens protein tyrosine phosphatase, non-receptor type 22 (PTPN22), transcript variant 3 |
Database Link | |
Background | The PTPN22 gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. |
Synonyms | PTPN8, Lymphoid phosphatase, LyP, LYP1, LYP2, PEP |
Note | Molecular Weight: 91705 Da |
Reference Data | |
Protein Families | Druggable Genome, Phosphatase |
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