Septin 2 (SEPT2) (C-term) Rabbit Polyclonal Antibody

CAT#: AP53852PU-N

Septin 2 (SEPT2) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of SEPT2 Antibody (C-term) in NCI-H460 cell line lysates (35ug/lane). This demonstrates the SEPT2 antibody detected the SEPT2 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1,000.
  Western blotting: 1/100-1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 279-309 amino acids from the C-terminal region of Human SEPT2
• Specificity: Recognizes SEPT2 (C-term).
• Formulation: PBS with 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column followed by peptide Affinity purification
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens septin 2 (SEPT2), transcript variant 1
• Database Link:
  Entrez Gene 4735 Human
• Background: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.
• Synonyms: SEPT2, DIFF6, KIAA0158, NEDD5, NEDD-5, Septin2, SEPT-2
• Note: Molecular Weight: 41487 Da