SFTPB (Center) Rabbit Polyclonal Antibody

CAT#: AP53885PU-N

SFTPB (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis using SFTPB Antibody (Center) in HepG2 cell line lysates (35ug/lane). This demonstrates the SFTPB antibody detected the SFTPB protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1,000.
  Western blotting: 1/100-1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 128-158 amino acids from the Central region of Human SFTPB
• Specificity: Recognizes SFTPB (Center).
• Formulation: PBS with 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column followed by peptide Affinity purification
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens surfactant protein B (SFTPB), transcript variant 1
• Database Link:
  Entrez Gene 6439 Human
• Background: SFTPB is the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.
• Synonyms: Surfactant protein B, SP-B, SFTP3
• Note: Molecular Weight: 42117 Da

Reference Data

• Protein Families: Druggable Genome, Secreted Protein