Nav1.5 (SCN5A) Mouse Monoclonal Antibody [Clone ID: OTI4B11]

CAT#: CF815388

Carrier-free (BSA/glycerol-free) SCN5A mouse monoclonal antibody,clone OTI4B11

Specifications

Product Data

• Clone Name: OTI4B11
• Applications: WB
• Recommended Dilution: WB1:1000
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Full length human recombinant protein of human SCN5A (NP_932173) produced in E.coli.
• Formulation: Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
• Reconstitution Method: For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Unconjugated
• Storage: Shipped at -20°C or with ice packs, Upon delivery store at -20°C. Dilute in PBS(pH7.3) if necessary. Stable for 12 months from date of receipt. Avoid repeated freeze-thaws.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 226.8 kDa
• Gene Name: Homo sapiens sodium voltage-gated channel alpha subunit 5 (SCN5A), transcript variant 1, mRNA.
• Database Link:
  NP_932173
  Entrez Gene 6331 Human
  UniProt ID Q14524
• Background: The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
• Synonyms: CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; Nav1.5; PFHB1; SSS1; VF1

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Sodium, Transmembrane