BMI1 Rabbit Polyclonal Antibody

CAT#: TA301482

Rabbit Polyclonal Antibody against Bmi1


USD 424.00

In Stock*

Size
    • 100 ul

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Specifications

Product Data
Applications WB
Recommended Dilution Immunohistochemistry, Western Blot: 2 ug/ml, Immunocytochemistry/ Immunofluorescence: 1:50-1:200
Reactivities Human, Mouse
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen A synthetic peptide made to an internal region (within residues 1-100) of the human Bmi1 protein. [Swiss-Prot# P35226]
Formulation Tris-glycine, 150mM NaCl and 0.05% sodium azide
Concentration lot specific
Purification Immunogen affinity purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name BMI1 proto-oncogene, polycomb ring finger
Background The Bmi1 oncogene has been shown to induce telomerase activity and immortalize human mammary epithelial cells. Bmi1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway. Bmi1 is also important in maintaining stem cells' ability to self renew. It has also been termed an oncogene with aberrant expression in various carcinomas. It has been shown to be a negative regulator of p19Arf, Ink4a (p14Arf) and tp53 known tumor repressors. Ablation of Bmi1 is required for short term survival of cancer cells.
Synonyms BMI1; FLVI2; PCGF4; RNF51
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors

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