TDP43 (TARDBP) Rabbit Polyclonal Antibody

CAT#: TA301509

Rabbit Polyclonal Antibody against TARDBP


USD 424.00

2 Weeks*

Size
    • 100 ul

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Specifications

Product Data
Applications WB
Recommended Dilution ELISA, Western Blot: 0.5-2 ug/ml, Immunohistochemistry: 1:250, Immunohistochemistry-Paraffin: 1:250, Immunocytochemistry/ Immunofluorescence: 1:100-1:1000
Reactivities Human, Primate, Mouse, Xenopus, Zebrafish, Chicken
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen A synthetic peptide to a C-terminal region [within residues 350-414] of the human TARDBP protein. [Swiss-Prot# Q13148]
Formulation Tris-glycine, 150mM NaCl and 0.05% sodium azide
Purification Immunogen affinity purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name TAR DNA binding protein
Background The HIV1 virus gives rise to acquired immunodeficiency syndrome (AIDS). HIV1 contains an RNA genome which produces chromosomally integrated DNA during cellular replication. Gene activation of HIV1 by the transactivator Tat requires an RNA regulatory element TAR which is located downstream of the transcription initiation site. TARDBP is a transcriptional repressor that binds to the chromosomally integrated TAR DNA, preventing HIV1 expression. Additionally, this protein regulates alternative splicing of the CTFR gene, a similar pseudogene on chromosoome 20. TARDBP has also been recently been shown to abnormally accumulate in the post-mortem brain tissue of individuals diagnosed with ALS (Amyotrophic Lateral Sclerosis) and FTD (Frontal Temporal Dementia). This long-awaited conncection between these two diseases provides an explanation for the observed clinical overlap.
Synonyms ALS10; TDP-43
Reference Data
Protein Families Transcription Factors

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.