FAIM1 (FAIM) Rabbit Polyclonal Antibody

CAT#: TA306048

Rabbit Polyclonal FAIM Antibody

Product Images

Western blot analysis of FAIM in human spleen tissue lysate with FAIM antibody at (A) 5 and (B) 10 ug/ml.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 5 - 10 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: FAIM antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human FAIM .
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: Fas apoptotic inhibitory molecule
• Database Link:
  NP_001028202
  Entrez Gene 23873 MouseEntrez Gene 55179 Human
  UniProt ID Q9NVQ4
• Background: The susceptibility of primary splenic B cells to Fas-mediated apoptosis is regulated in a receptor-specific fashion. Terminal effectors of B cell Fas-resistance include the known anti-apoptotic proteins Bcl-xL, FLIP, and a recently identified protein termed FAIM. This molecule is broadly expressed in various tissues and exists in at least three isoforms. It is thought that resistance to Fas killing via increased expression of FAIM protects foreign antigen-specific B cells during interactions with FasL-bearing T cells whereas autoreactive B cells are deleted via Fas-dependent cytotoxicity. More recent results have indicated that FAIM interacts with both Trk and p75 neurotrophin receptor and may play a role in promoting neurite outgrowth in different neuronal systems by a mechanism involving the activation of NF-kappaB and the Ras-ERK pathway.
• Synonyms: FAIM1