NKIRAS1 Rabbit Polyclonal Antibody

CAT#: TA306083

Rabbit Polyclonal KappaB ras Antibody

Product Images

Western blot analysis of KappaB ras in 293 cell lysate with KappaB ras antibody at (A) 2 and (B) 4 ug/ml.

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  Immunohistochemistry of KappaB ras in human lymph node tissue with KappaB ras antibody at 1 ug/ml.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 2 - 4 ug/mL, ICC: 1 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: KappaB ras antibody was raised against a 18 amino acid peptide from near the center of human KappaB ras 1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: NFKB inhibitor interacting Ras like 1
• Database Link:
  NP_065078
  Entrez Gene 69721 MouseEntrez Gene 305751 RatEntrez Gene 28512 Human
  UniProt ID Q9NYS0
• Background: KappaB ras-1 (kappaB-ras-1) and kappaB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with IkappaB (IkappaB), an inhibitor of the transcription factor NF-kappaB. IkappaB exists in two homologous forms, IkappaB-alpha and IkappaB-beta, although IkappaB-beta contains a unique 47-amino acid region within its ankyrin domain. While inactive IkappaB-alpha-NF-kappaB complexes can shuttle in and out of the nucleus, IkappaB-beta-NF-kappaB complexes are retained exclusively in the cytoplasm. It is suggested that kappaB-ras proteins preferentially bind to the IkappaB-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of IkappaB-beta and regulating the rate of degradation of IkappaB-beta. This antibody detects both kappaB-ras1 and kappaB-ras2.
• Synonyms: kappaB-Ras1; KBRAS1