BMI1 Rabbit Polyclonal Antibody

CAT#: TA306298

Rabbit Polyclonal BMI-1 Antibody


USD 430.00

In Stock*

Size
    • 100 ug

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Specifications

Product Data
Applications IF, WB
Recommended Dilution WB: 0.5 - 2 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen BMI-1 antibody was raised against a peptide corresponding to 15 amino acids near the center of human BMI-1.
Formulation PBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name BMI1 proto-oncogene, polycomb ring finger
Background The transcriptional repressor BMI-1 was first identified as a proto-oncogene frequently activated by Moloney murine leukemia proviral insertions in mice and cooperating with c-myc in the generation of mouse lymphomas . BMI-1 is involved in segment specification, cell growth and maintenance, transcriptional regulation, and chromatin modification. A major target of BMI-1 is the ink4a locus which encodes tumor suppressor proteins p16 and p19Arf, which are important in tumor progression and thought to be critical in cell proliferation and senescence (2). Recent studies have also shown that BMI-1 is required for the maintenance of adult normal and leukemic stem cells (3), suggesting that BMI-1 could an attractive therapeutic target for stem cell proliferation and renewal as well as for anti-cancer strategies.
Synonyms BMI1; FLVI2; PCGF4; RNF51
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors

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