TBC1D1 Rabbit Polyclonal Antibody

CAT#: TA306433

Rabbit Polyclonal TBC1D1 Antibody

Product Images

Western blot analysis of TBC1D1 expression in (A) 293 and (B) Daudi cell lysate with TBC1D1 antibody at 2ug/ml.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1 - 4 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TBC1D1 antibody was raised against a 22 amino acid synthetic peptide from near the carboxy terminus of human TBC1D1. The immunogen is located within the last 50 amino acids of TBC1D1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: TBC1 domain family member 1
• Database Link:
  NP_055988
  Entrez Gene 23216 Human
  UniProt ID Q86TI0
• Background: TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain and presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2/USP6, yeast Bub2, and CDC16. TBC1D1 and TBC1D4 (AS160) have been demonstrated to be Rab GAPs (GTPase-activating proteins) that link upstream to Akt and phosphoinositide 3-kinase and downstream to Rabs involved in trafficking of GLUT4 vesicles. TBC1D1 regulates insulin-mediated GLUT4 translocation through its GAP activity, and is a likely Akt substrate. Mutations in the Tbc1d1 gene lead to some cases of severe human obesity.
• Synonyms: TBC; TBC1

Reference Data

• Protein Families: Druggable Genome