SLC22A17 Rabbit Polyclonal Antibody

CAT#: TA306595

Rabbit Polyclonal Slc22A17 Antibody

Product Images

Western blot analysis of Slc22A17 in SK-N-SH lysate with Slc22A17 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

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  Immunofluorescence of Slc22A17 in rat kidney tissue cells with Slc22A17 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Slc22A17 antibody was raised against a 14 amino acid peptide near the carboxy terminus of the human Slc22A17.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: solute carrier family 22 member 17
• Database Link:
  NP_057693
  Entrez Gene 59049 MouseEntrez Gene 305886 RatEntrez Gene 51310 Human
  UniProt ID Q8WUG5
• Background: The Slc22 family of organic anion and cation transporters (OATs, OCTs, OCTNs) are transmembrane proteins expressed predominantly in kidney and liver. Each contain 12 predicted alpha-helical transmembrane domains (TMDs) and one large extracellular loop between TMDs 1 and 2. Transporters of the SLC22 family function in different ways such as uniporters that mediate facilitated diffusion in either direction (OCTs), as anion exchangers (OAT1, OAT3 and URAT1), and as Na(+)/l-carnitine cotransporter (OCTN2). Slc22 family members participate in the absorption and/or excretion of drugs, xenobiotics, and endogenous compounds in intestine, liver, and kidney, and perform homeostatic functions in brain and heart. Mutations in the Slc22 family may cause specific diseases such as primary systemic carnitine deficiency or idiopathic renal hypouricemia and may change drug absorption or excretion. Recent studies show the expression of Slc22A17 as receptor for Lipocalin 2 is relatively high in hematopoietic stem cells.
• Synonyms: 24p3R; BOCT; BOIT; hBOIT; NGALR; NGALR2; NGALR3

Reference Data

• Protein Families: Druggable Genome, Transmembrane