FTO Rabbit Polyclonal Antibody

CAT#: TA306766

Rabbit Polyclonal FTO Antibody

Product Images

Western blot analysis of FTO in human uterus tissue lysate with FTO antibody at (A) 1 and (B) 2 ug/ml.

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  Western blot analysis of FTO in human uterus tissue lysate with FTO antibody at (A) 1 and (B) 2ug/ml.

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  Immunohistochemistry of FTO in mouse brain tissue with FTO antibody at 2.5ug/ml.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: FTO antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human FTO. The immunogen is located within the first 50 amino acids of FTO.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: fat mass and obesity associated
• Database Link:
  NP_001073901
  Entrez Gene 79068 Human
  UniProt ID Q9C0B1
• Background: Rising obesity rates are rapidly becoming a growing health concern in the developing world. The fat mass and obesity associated gene (FTO) is the first gene discovered to contribute to common forms of human obesity. FTO is a member of the non-heme dioxygenase superfamily, encoding a 2-oxoglutarate-dependent nucleic acid demethylase whose mRNA is widely expressed, especially in neurons of feeding-related nuclei of the brain. FTO mRNA in the arcuate nucleus in mice is up-regulated by feeding and down-regulated during fasting, although the opposite pattern has been observed in rats. At least four isoforms of FTO are known to exist.
• Synonyms: ALKBH9; BMIQ14; GDFD