SCF (KITLG) Rabbit Polyclonal Antibody

CAT#: TA306779

Rabbit Polyclonal SCF Antibody

Product Images

Western blot analysis of SCF in rat brain tissue lysate with SCF antibody at (A) 1 and (B) 2 ug/ml.

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  Immunohistochemistry of SCF in mouse brain tissue with SCF antibody at 2.5 ug/ml.

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  Immunofluorescence of SCF in Human Brain tissue with SCF antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: SCF antibody was raised against an 18 amino acid peptide from near the center of human SCF.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: KIT ligand
• Database Link:
  NP_000890
  Entrez Gene 60427 RatEntrez Gene 4254 Human
  UniProt ID P21583
• Background: Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-g, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
• Synonyms: FPH2; FPHH; Kitl; KL-1; MGF; SCF; SF; SHEP7

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer