TBKBP1 Rabbit Polyclonal Antibody

CAT#: TA306842

Rabbit Polyclonal Prosapip2 Antibody

Product Images

Western blot analysis of Prosapip2 in rat liver tissue lysate with Prosapip2 antibody at 1 ug/ml.

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  Immunohistochemistry of Prosapip2 in rat liver tissue with Prosapip2 antibody at 5 ug/ml.

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  Immunofluorescence of Prosapip 2 in rat liver tissue with Prosapip 2 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Prosapip2 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human Prosapip2.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: TBK1 binding protein 1
• Database Link:
  NP_055541
  Entrez Gene 73174 MouseEntrez Gene 266764 RatEntrez Gene 9755 Human
  UniProt ID A7MCY6
• Background: Prosapip2 (TBKBP1) is essential for signal transduction during viral infection thus plays a major role in the TNF/NF-kappaB pathway. It is an adaptor protein that constitutively binds TBK1 (TANK-binding kinase) and IKBKE and may play a role in antiviral innate immunity. Prosapip2 is a 615 amino acid adaptor protein belonging to the fibrillar collagen family, consisting of trimers of identical alpha 1 chains which are linked to each other by interchain disulfide bonds. It has a ubiquitous expression with highest levels in ovary, followed by the neuronal system. Prosapip2 binds to TBK1 and helps in the activation of IRF3 which controls the expression of antiviral genes during infection. Recent studies show that Prosapip2 is an interaction partner of ProSAP2/Shank3 and actin, suggesting a role as a linker molecule between postsynaptic density and the cytoskeleton.
• Synonyms: ProSAPiP2; SINTBAD

Reference Data

• Protein Pathways: RIG-I-like receptor signaling pathway