Munc 13 4 (UNC13D) Rabbit Polyclonal Antibody

CAT#: TA308332

Rabbit Polyclonal antibody to UNC13D (unc-13 homolog D (C. elegans))

Product Images

Sample (30 ug of whole cell lysate). A: Jurkat. B: K562. 5% SDS PAGE. TA308332 diluted at 1:1000.

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  Immunohistochemical analysis of paraffin-embedded Stomach, using UNC13D (TA308332) antibody at 1:100 dilution.

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  Immunofluorescence analysis of methanol-fixed HeLa, using Munc 13-4 (TA308332) antibody at 1:500 dilution.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region within amino acids 1029 and 1090 of Munc 13-4 (Uniprot ID#Q70J99)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 123 kDa
• Gene Name: unc-13 homolog D
• Database Link:
  NP_954712
  Entrez Gene 201294 Human
  UniProt ID Q70J99
• Background: This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder. [provided by RefSeq]
• Synonyms: FHL3; HLH3; HPLH3; Munc13-4