LBP Rabbit Polyclonal Antibody

CAT#: TA308490

Rabbit Polyclonal antibody to LBP (lipopolysaccharide binding protein)

Product Images

Sample (30 ug whole cell lysate). A:H1299. 7.5% SDS PAGE. TA308490 diluted at 1:500

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  Immunohistochemical analysis of paraffin-embedded Gastric N+T, using LBP (TA308490) antibody at 1:100 dilution.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 166 and 467 of LBP (Uniprot ID#P18428)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 53 kDa
• Gene Name: lipopolysaccharide binding protein
• Database Link:
  NP_004130
  Entrez Gene 3929 Human
  UniProt ID P18428
• Background: The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene. [provided by RefSeq]
• Synonyms: BPIFD2

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Toll-like receptor signaling pathway