Dopamine Transporter (SLC6A3) Rabbit Polyclonal Antibody

CAT#: TA309111

Rabbit Anti-Dopamine Transporter, C-Terminus, Human Antibody

Product Images

Western blot of human caudate lysate showing specific immunolabeling of the ~88k DAT protein.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:100, IHC: 1:1000
• Reactivities: Human, Monkey, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to amino acid residues from the intracellular C-terminal region conjugated to KLH
• Formulation: 100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 88 kDa
• Gene Name: solute carrier family 6 member 3
• Database Link:
  NP_001035
  Entrez Gene 13162 MouseEntrez Gene 574143 MonkeyEntrez Gene 6531 Human
  UniProt ID Q01959
• Background: This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.
• Synonyms: DAT; DAT1; PKDYS

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Parkinson's disease