G protein alpha 16 (GNA15) Rabbit Polyclonal Antibody

CAT#: TA318890

Rabbit polyclonal anti-Ga15/16 antibody

Product Images

Western blot analysis of G alpha-15 expression in 3T3 cell lysate.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 0.5-4ug/ml, IHC: 5-20ug/ml
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide surrounding amino acid 356of human G 15
• Formulation: 100 µg (0.5 mg/ml) affinity purified rabbit anti-Ga15 polyclonal antibody in PBS (pH 7.2) containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: G protein subunit alpha 15
• Database Link:
  NP_002059
  Entrez Gene 14676 MouseEntrez Gene 89788 RatEntrez Gene 2769 Human
  UniProt ID P30679
• Background: Ga16 is the only heterotrimeric G protein with a restricted expression pattern in hematopoietic cells. Differentiation of promyelocytic cells leads to decreased expression of Ga16. The G protein is known to couple a large number of G protein-coupled receptors to PLC-β and can lead to production of the secondary messengers diacylglycerol and inositol phosphates. Targeted deletion of Ga15, a mouse orthologue of human Ga16, causes reduced C5a receptor signaling. Ga16 serves as a marker, in addition to CD34, for hematopoietic progenitor cells.
• Synonyms: GNA16

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Calcium signaling pathway