INSIG1 Rabbit Polyclonal Antibody

CAT#: TA318983

Rabbit polyclonal anti-Insig1 antibody

Product Images

Western blot analysis of InSig1 expression in Jurkat cell lysate.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 0.5-4 ug/ml
• Reactivities: Bovine, Hamster, Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide surrounding amino acid 248 of rat Insig1
• Formulation: 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: insulin induced gene 1
• Database Link:
  NP_938150
  Entrez Gene 64194 RatEntrez Gene 231070 MouseEntrez Gene 3638 Human
  UniProt ID O15503
• Background: Insulin-induced gene (InSig) localizes in the endoplasmic recticulum(ER) and is highly expressed in the liver and fibroblast cell lines. InSig1 and InSig2 play important roles in the regulation of cholesterol biosynthesis. Sterol induces InSig1 binding to the sterol-sensing domain of SREBP cleavage-activating protein (SCAP). Both InSig1 and Insig2 prevent the export of SCAP from the ER and thus, inhibit cholesterol synthesis by preventing the proteolytic cleavage of SREBPs by the Golgi enzymes.
• Synonyms: CL-6; CL6

Reference Data

• Protein Families: Druggable Genome, Transmembrane