TRIM29 Rabbit Polyclonal Antibody

CAT#: TA319472

Rabbit polyclonal anti-ATDC antibody

Product Images

affinity purified anti-ATDC antibody shows reactivity by dot blot with acetylated and non-acetylated forms of the immunizing peptide. This antibody is predicted to recognize both acetylated (AcK116) and non-acetylated forms of ATDC protein. Personal communication, Z. Yuan, H Lee Moffitt Cancer Center and Research Institute.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1:100,000, WB: 1:500 to 3,000
• Reactivities: Bovine, Chimpanzee, Human, Macaque, Horse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to an internal portion of human ATDC protein around lysine 116.
• Formulation: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: tripartite motif containing 29
• Database Link:
  NP_036233
  Entrez Gene 23650 Human
  UniProt ID Q14134
• Synonyms: ATDC
• Note: Ataxia-telangiectasia group D-associated protein (ATDC), also called tripartite motif-containing protein 29 (TRIM29), is a novel Histone deacetylase (HDAC) associated protein. Its function is tightly regulated by HDAC. ATDC Lysine 116 (K116) is acetylated and has a significant functional role in regulating cell survival and tumorigenesis. ATDC is expressed in placenta, prostate and thymus, and is over expressed in pancreatic and cervical tumors. Its function in tumor cells is not fully understood. It is constitutively phosphorylated by PKC on serine/threonine in A431 cells. The ATDC gene product is one of a group of proteins that share multiple zinc finger motifs and an adjacent leucine zipper motif. These proteins have been proposed to form homo- or heterodimers involved in nucleic acid binding, consistent with the fact that many of these proteins appear to be transcriptional regulatory factors involved in carcinogenesis and/or differentiation. The likelihood that the ATDC gene product is involved in transcriptional regulation could explain the pleiomorphic characteristics of AT, including abnormal cell cycle regulation.

Reference Data

• Protein Families: Transcription Factors