Ahsa1 Rat Monoclonal Antibody [Clone ID: 25F2.D9]

CAT#: TA319551

Rat monoclonal anti-AHA1 antibody


USD 530.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Clone Name 25F2.D9
Applications IHC, WB
Recommended Dilution ELISA: 1:20,000, WB: 1:1,000, IHC: 5-10 ug/mL
Reactivities Chimpanzee, Human, Mouse
Host Rat
Clonality Monoclonal
Immunogen This Protein G purified monoclonal antibody was produced in rats by repeated immunizations with full length recombinant mouse AHA1 protein followed by hybridoma development.
Formulation 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Concentration lot specific
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name AHA1, activator of heat shock protein ATPase 1
Synonyms AHA1; C14orf3; p38
Note Activator of Hsp90 ATPase (AHA1) stimulates the inherent ATPase cycle of Hsp90, which is essential for its chaperone activity in vivo. The activation and/or stability of many of the key regulatory and signaling proteins of the eukaryotic cell depend on their interaction with the Hsp90 molecular chaperone. Hsp90 is assisted and regulated by co-chaperones that participate in an ordered series both to assist client-protein recruitment or release and to modulate progress through the ATPase coupled chaperone cycle. Structural analysis and mutagenesis show that binding of the N-terminal domain of AHA1 to Hsp90 promotes a conformational switch in the middle-segment catalytic loop (aa 370–390) of Hsp90 that exposes the catalytic Arg380 and enables its interaction with ATP in the N-terminal nucleotide-binding domain of the chaperone. Recent studies show that AHA1 modulates Hsp90-dependent stability of the folding of the cystic fibrosis transmembrane conductance regulator (CFTR) in the endoplasmic reticulum (ER). Down-regulation of AHA1 rescues misfolding of CFTR in cystic fibrosis.
Reference Data

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