Nkx2.2 (NKX2-2) Rabbit Polyclonal Antibody

CAT#: TA319689

Rabbit Polyclonal NKX2-2 Antibody

Product Images

Western blot analysis of NKX2-2 in rat kidney tissue lysate with NKX2-2 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

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  Immunohistochemistry of NKX2-2 in human kidney tissue with NKX2-2 antibody at 2.5 ug/mL.

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  Immunofluorescence of NKX2-2 in human kidney tissue with NKX2-2 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: NKX2-2 antibody was raised against a 19 amino acid synthetic peptide near the center of human NKX2-2.
• Formulation: NKX2-2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: NKX2-2 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: NK2 homeobox 2
• Database Link:
  NP_002500
  Entrez Gene 18088 MouseEntrez Gene 366214 RatEntrez Gene 4821 Human
  UniProt ID O95096
• Background: NKX2-2 Antibody: NKX2-2 (NK2 homeobox 2) is a member of a family of transcription factors that are involved in embryonic development and cell fate. NKX2-2 is crucial in the development of pancreatic islet cell differentiation and activates the ghrelin-promoter in these cells. NKX2-2 is expressed at the onset of pancreatic epithelium formation and becomes restricted to mature α-, β- and PP cells, and in NKX2-2-null mice embryos, all β-cells and most a-cells are replaced by ghrelin-positive cells. NKX2-2 is also thought to be involved in ventral neuronal patterning and floor plate development and commissural axon guidance.
• Synonyms: NKX2.2; NKX2B

Reference Data

• Protein Families: Transcription Factors
• Protein Pathways: Maturity onset diabetes of the young