LRRFIP1 Rabbit Polyclonal Antibody

CAT#: TA319771

Rabbit Polyclonal LRRFIP1 Antibody

Product Images

Western blot analysis of LRRFIP1 in human colon tissue lysate with LRRFIP1 antibody at 1 ug/mL.

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  Immunohistochemistry of LRRFIP1 in human colon tissue with LRRFIP1 antibody at 5 ug/mL.

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  Immunofluorescence of LRRFIP1 in human colon tissue with LRRFIP1 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: LRRFIP1 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human LRRFIP1.
• Formulation: LRRFIP1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: LRRFIP1 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: leucine rich repeat (in FLII) interacting protein 1
• Database Link:
  NP_004726
  Entrez Gene 9208 Human
  UniProt ID Q32MZ4
• Background: LRRFIP1 Antibody: LRRFIP1, also known as GC-binding factor 2 (GCF2), is a 738 amino acid transcriptional repressor that mainly plays a cytoskeletal role. It is primarily localized in the cytoplasm and preferentially binds to GC-rich dsDNA, but will also bind directly to dsRNA as well. The RNA binding domain encompasses a lysine-rich motif. LRRFIP1 interacts with the mammalian Flightless I (Fli-I) and is a key component in the cytoskeletal regulation of platelet function. LRRFIP1 and the related protein LRRFIP2 may modulate canonical WNT signaling and mediate the IRF3-induced production of type I interferon via a beta-catenin-dependent pathway.
• Synonyms: FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2; HUFI-1; TRIP

Reference Data

• Protein Families: Transcription Factors