TOX1 (TOX) Rabbit Polyclonal Antibody

CAT#: TA319787

Rabbit Polyclonal TOX Antibody

Product Images

Western blot analysis of TOX in human colon tissue lysate with TOX antibody at (A) 1 and (B) 2 ug/mL.

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  Immunofluorescence of TOX in human colon tissue with TOX antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IF: 20 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TOX antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human TOX.
• Formulation: TOX Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: TOX Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 58 kDa
• Gene Name: thymocyte selection associated high mobility group box
• Database Link:
  NP_055544
  Entrez Gene 9760 Human
  UniProt ID O94900
• Background: TOX Antibody: TOX (thymocyte selection-associated high mobility group (HMG) box protein) is a member of the HMG box family of DNA-binding proteins and likely plays a role in the regulation of T-cell development. It is a 526 amino acid nuclear protein and the expression of TOX is upregulated by pre-T cell receptor (pre-TCR) and TCR activation in immature thymocytes. TOX-mediated positive selection is associated with up-regulation of RUNX3 and is calcineurin dependent. TOX-dependent transition to the CD4+CD8 stage is required for development of class II major histocompatibility complex-specific T cells.
• Synonyms: TOX1

Reference Data

• Protein Families: Transcription Factors