Smad Interacting Protein 1 (ZEB2) Rabbit Polyclonal Antibody

CAT#: TA319793

Rabbit Polyclonal ZEB2 Antibody

Product Images

Western blot analysis of ZEB2 in Jurkat cell lysate with ZEB2 antibody at (A) 1 and (B) 2ug/mL.

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  Immunocytochemistry of ZEB2 in Jurkat cells with ZEB2 antibody at 20 ug/mL.

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  Immunofluorescence of ZEB2 in Jurkat cells with ZEB2 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 20 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: ZEB2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human ZEB2.
• Formulation: ZEB2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: ZEB2 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: zinc finger E-box binding homeobox 2
• Database Link:
  NP_001165124
  Entrez Gene 24136 MouseEntrez Gene 311071 RatEntrez Gene 9839 Human
  UniProt ID O60315
• Background: ZEB2 Antibody: ZEB2, initially identified as Smad interacting-protein 1, is normally located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Like the homologous ZEB1, ZEB2 inhibits the transcription of the E-cadherin gene and induces epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing, in vitro. ZEB2 can also protect cells from DNA damage-induced apoptosis, suggesting that its expression may contribute to tumor progression. Recent evidence has shown that ZEB2 is often observed in the cytoplasm in numerous cancer tissues, indicating that its localization may be regulated in normal and tumor tissues. Mutations in this gene are also associated with Hirschsprung disease/Mowat-Wilson syndrome.
• Synonyms: HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B

Reference Data

• Protein Families: Druggable Genome, Transcription Factors