CITED2 Rabbit Polyclonal Antibody

CAT#: TA319813

Rabbit Polyclonal CITED2 Antibody

Product Images

Western blot analysis of CITED2 in Jurkat cell lysate with CITED2 antibody at (A) 1 and (B) 2 ug/mL.

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  Immunofluorescence of CITED2 in Jurkat cells with CITED2 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: CITED2 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CITED2.
• Formulation: CITED2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: CITED2 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 30 kDa
• Gene Name: Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2
• Database Link:
  NP_001161860
  Entrez Gene 17684 MouseEntrez Gene 114490 RatEntrez Gene 10370 Human
  UniProt ID Q99967
• Background: CITED2 Antibody: CITED2 was initially identified as a potential transcriptional activator with significant homology to MSG1, a melanocyte-specific nuclear protein. CITED2 interacts with the histone acetyltransferase p300/CBP and acts as a coactivator to several DNA-binding transcription factors such as HIF-1 and AP-2. CITED2 also controls proliferation of mouse embryonic fibroblasts via the polycomb group genes Bmi-1 and Mel18 and the tumor suppressor Ink4a/Arf. CITED2 has also been found to be an essential regulator of adult hematopoietic stem cells (HSCs), with conditional deletion of CITED2 in the adult mouse resulting in the loss of HSCs, multilineage bone marrow failure and increased lethality.
• Synonyms: ASD8; MRG-1; MRG1; P35SRJ; VSD2

Reference Data

• Protein Families: Druggable Genome, Transcription Factors